David Geffen School of Medicine at UCLA
Department of Human Genetics

Speaker Series - Fall Quarter 2017

Mondays, 11am - 12pm, Gonda Building First Floor Conference Room, 1357

Mon, Oct 09
Causes and Consequences of Human Genomic Variation
Sohini Ramachandran, PhD; Associate Professor of Ecology and Evolutionary Biology; Associate Professor of Computer Science; Director, Center for Computational Molecular Biology; Brown University
Contact & Intro: Jazlyn Mooney
View details »

ABSTRACT: Determining the genomic elements underlying adaptive evolution and diseases in a species is essential for connecting genetic variation to phenotypes and fitness, but current statistical methods overlook the confounding effect population histories have on the identification and localization of adaptive and disease-associated mutations. I'll discuss two methods developed in my laboratory that (i) model the complex interaction between various modes of selection and population histories; and (ii) accurately identify and localize mutations, genes, and pathways underlying adaptive traits and disease for further experimental validation. These methods can be extended and applied to existing and emerging genome-wide polymorphism and next-generation sequencing datasets for humans and a range of other organisms. Our goal is to yield new insight into the interaction between selection and dynamic population histories in generating human genetic diversity and the human phenotype.

Thu, Nov 16
Thursday, November 16, 2017 at 10:00am
Shared risk factors for cardiovascular disease and dementia – epidemiologic, genetic and causal aspects
Ruth Frikke-Schmidt, MD, DMSc, PhD, Chief Physician, Clinical Research Associate Professor; Department of Clinical Biochemistry KB 3-01-1; Rigshospitalet, University of Copenhagen
Contact & Intro: Paivi Pajukanta x 72011
View details »

ABSTRACT: Major contributors to morbidity and disability in aging populations are cardio- and cerebrovascular disease and dementia. These disease-entities are highly interrelated, however large fractions of the underlying pathogenesis are not well understood. Robust data on epidemiologic, genetic and causal associations will increase our understanding of the interrelationship between cardio- and cerebrovascular disease and dementia, and will have the potential to make the basis for targeted preventive strategies and treatment.

Previous Quarters